Alpers Disease Research Paper

Words: 502
Pages: 3

Alpers disease is a serious disease that affects the mitochondria. Children

at the age of 2-4 are prone to developing the disease. With this disease muscle-,

nerve-, and brain-related things are affected. People with this condition usually have

three common symptoms: seizures that do not improve with treatment, loss of

movement and mental improvement, and liver disease. There are cures discovered

yet but there are symptom slowing treatments. People who have this disease

usually have a life expectancy of a few months to about ten years.

With this disease the POLG gene creates mutations. This POLG gene is

responsible for sending signals to make a protein part called polymerase gamma

(pol y) that Pol y checks the
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Because of that this, the cell lacks cellular energy (ATP). This lack of ATP causes the

symptoms of Alpers disease.

The mitochondria is supposed to do a biological process. The process is

called cellular respiration. It takes air and sugar from the food we eat and from when

we breathe and makes it into ATP, carbon dioxide, and water.

But with this disease you don't have the ability to use glucose as well to make energy

then with normal mitochondria. And that creates the symptoms of the disease. Alpers disease affects one in 100,000 cases. Alpers disease is a rare,

progressive neurodegenerative disease of the brain that happens in children. The

symptoms are both mental, like not learning and behavioral problems. And physical

symptoms, like liver failure and/or seizures. People who live with this disease have a

life expectancy of a few months to about 10-25 years depending on when the disease


On a daily basis researchers research Alpers disease while people battle the

disease. They study the disease and by doing that they learn more about it.