Essay on Blood Thinners For Dummies

Submitted By DAblanedo
Words: 363
Pages: 2

Anticoagulants lengthen the time it takes to form a blood clot.
warfarin (Coumadin) enoxaparin (Lovenox) argatroban dabigatran (Pradaxa) rivaroxaban (Xarelto) apixaban (Eliquis)

Antiplatelets prevent platelets from clumping together to form a clot.
clopidogrel (Plavix) prasugrel (Effient) ticagrelor (Brilinta)

Seven South risk factors: inactivity, central venous catheter, cancer, chemo, afib, dehydration, sickle cell, valve defect or surgery

Other risk factors: DVT/PE history, over age 60, obesity, smoking, trauma to vein (surgery, fracture), pregnancy / postpartum, birth control pills

Lab Tests

PT (Prothrombin): Prothrombin is the circulating precursor to thrombin, which catalyzes the conversion of fibrinogen into fibrin. This test measures the integrity of the extrinsic and common pathways of coagulation.

PTT/aPTT (Activated Partial Thromboplastin Time): This test measures clotting time from the activation of clotting factor XII, through the formation of fibrin clot (intrinsic and common pathways of coagulation).

INR (International Normalized Ratio): Due to variability of thromboplastin and analyzers (used by labs to clot blood samples), it has been difficult to establish agreeable prothrombin levels (PT) between laboratories. To arrive at a consensus on adequate coagulation, the (INR) calculation was developed. This calculation helps to standardize PT values so that test results obtained using different thromboplastins and coagulation analyzers are equivalent. INR = (PT / mean normal PT).

Anti-Xa (aka Heparin Level): When present at therapeutic levels, heparin (and low molecular weight heparin) do not always and/or significantly prolong the activated PTT. Therefore, a PTT test may not accurately reflect