An unnamed North Korean Foreign Ministry spokesman claimed the panel was US-orchestrated and that Washington should mind its own business.
In the statement carried on Friday by North Korea's state news agency, the spokesman describes the report as "sheer lies" and says North Koreans enjoy "genuine rights."
The statement was in response to a hard-hitting report issued on Monday by the three-member UN commission of inquiry that recommended a referral of its findings to the UN Security Council and the International Criminal Court.
"This is an extremely dangerous politically-motivated provocation aimed to tarnish the image of the dignified DPRK and ramp up pressure on it in a bid to bring down its social system," said the statement, referring to the North by the initials of its formal name, the Democratic People's Republic of Korea.
Findings of the commission
The three-member commission, chaired by a retired Australian judge, on Monday recommended an international criminal investigation. It warned North Korean leader Kim Jong Un may be held accountable for orchestrating widespread crimes against civilians.
The commission was established by the UN top human rights body. It conducted a year-long investigation but was unable to visit North Korea.
The UN Commission of Inquiry on Human Rights in North Korea published its report earlier in February with evidence of murder and rape inside the country's labour camps where political prisoners