Fear Conditioning: A Case Study

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The lateral hypothalamus area (LHA) has been commonly recognized as a crucial area in the modulation of the autonomic responses in defensive situations. Despite the LHA being critical in neuroanatomical substrate for behavior, the role in behavioral modulation in fear conditioning still remains unclear. To test the involvement of the LHA in the modulation of the behavioral and autonomic responses (conditioned emotional responses – CER) associated fear conditioning context model, we evaluated the effects of the reversible inhibition of the LHA neurotransmission by bilateral microinjections of cobalt chloride (CoCl2,1 mm) (a non-selective synapse blocker) 10 min before re-exposure to the aversive context of the contextual fear conditioning