Hemophilia is a lifelong, inherited disorder that causes abnormal bleeding. It is a disorder of one’s blood-clotting system, where the plasma part of the blood does not have enough protein to help blood clot. This means that if you have hemophilia, you will bleed for a longer time if you have a cut than others that do not have hemophilia. The danger of this disorder is that one can have deep internal bleeding or bleeding into one’s joints. There are three types of hemophilia, type A, B, and C. Type A is the most common type and is caused by the lack of clotting factor 8. Type B is the second most common type and is caused by the lack of clotting factor 9. Type C is a mild type of hemophilia and is caused by the lack of clotting factor 11. The type of hemophilia one inherits depends on the clotting factor that is deficient. Hemophilia is a sex-linked recessive disorder, a genetic disease linked to a defective gene on the X chromosome. The gene that cause hemophilia A and B cannot be passed on from father to son, but hemophilia C can be passed by either parent. Most of the people diagnosed with hemophilia can trace back the disorder in their family for many generations. However, some people get hemophilia after a mutation has occurred in their clotting factor 8 or 9 gene; these people can then pass on this disorder to their children. For people with hemophilia in their family history, they can test their fetus during pregnancy to see if it has the disorder. The other way to diagnose the disease is to have a physical exam and analyze a blood sample to see if one does not have enough of a clotting factor. However, sometimes, the disorder cannot be diagnose until after a parent witnesses a bleeding problem with their children, or if one has gone under surgery and has resulted in too much bleeding. The main signs and symptoms of hemophilia include excessive bleeding and easy bruising. However, the degree of the bleeding depends on how severe one’s disorder is. People with mild hemophilia do not show signs of excessive bleeding until after a dental procedure, an accident, or surgery. Signs of external bleeding include heavy bleeding from a minor cut, nosebleeds for no reason, continuous bleeding, and bleeding in the mouth from losing a tooth. Signs of spontaneous bleeding include large, deep bruises, joint pain and swelling, blood in urine or stool. Emergency signs of hemophilia include sudden joint pain, painful, lasting headache, repeated vomiting, extreme fatigue, neck pain, and double vision. Internal bleeding from the kidney or bladder lead to blood in the urine, from the intestines or stomach lead to blood in the stool, from large muscles lead to large bruises. Internal bleeding of the brain is the most serious complication of hemophilia and shows emergency signs; it can happen after a bump on the head or a more serious injury. Since the disorder itself cannot be prevented because it is an inherited disorder, instead it can be managed and treated. The main treatment for hemophilia is replacement therapy. This is where one would take extra clotting factors by drip or injection. This, however, may have many complications and could cause more harm before the replacement therapy can start working. Other treatments include injection of the hormone desmopressin for mild hemophilia A, plasma infusions, antifibrinolytic medicines to use before dental work or to treat nose or mouth or intestinal bleeding, or gene therapy. Minor cuts and scrapes can be taken care of with pressure and bandages; small areas of bleeding beneath the skin can be taken care of with ice packs; minor bleeding in the mouth can be slowed down with ice pops. Maintaining physical activity can also help to keep one’s…
"MMMM d, y" October 6 2014
Hemophilia is rare hereditary coagulation disorder due to deficiency or reduced activity of factor VIII or factor VIIII. Hemophilia word came from Greek language where haimo means blood and philia is affection. Hemophilia sometimes called royal disease as it affected the large number of royal males during 19th and 20th centuries. Queen Victoria believed to be the carrier of Hemophilia B which she passed to her off springs.
Hemophilia is x linked recessive disorder…
- Chromosome number of gene disorder
Everyone inherits two sex chromosomes, X and Y, from his or her parents. A female inherits one X chromosome from her mother and one X chromosome from her father (XX). A male inherits one X chromosome from his mother and one Y chromosome from his father (XY). The gene that causes Hemophilia is located on the X chromosome.
–Type of disorder
Hemophilia is a rare bleeding disorder in which the blood doesn't clot normally. If you have Hemophilia…
Cancer Treatment Centers of America (“CTCA”) is a network of cancer hospitals providing state of the art cancer treatment in the United States. CTCA operates as a for profit specialty hospital and health care network with facilities in all regions of the contiguous United States. With patient cancer survival rates above national benchmarks, the Mother Standard of Care has proven to be an effective model for patient treatment and for business success.
CTCA has introduced both process innovations…
Sickle Cell Anemia and Hemophilia
Blood is a constantly circulating bodily fluid that provides the body with necessary substances such as nutrients and oxygen, and takes part in waste removal. Blood is made up of two components: blood cells and plasma. The plasma is the liquid portion and it makes up about half the content of blood. Plasma help in the clotting of blood with the help of proteins, and it also helps to transport substances through the blood. The other half of the blood is…
Have you ever gotten hurt while playing outside or because you fell? Most of us probably have, most of the time we bleed and soon enough our wound heals and the bleeding subsides. In about 1 in 5000 people that is not the case because they suffer from a rare blood disease known as Hemophilia. Like the majority of diseases, Hemophilia has causes, symptoms, and different types of information.
First, according to Microsoft Encarta 2008, Hemophilia is a group of hereditary genetic disorders…
Hemophilia is a rare and genetic blood clotting disorder affecting about 18,000 people in America today. It is a hereditary disorder that is passed from parent to child, normally from mothers to the sons. It can be carried by females and normally 1/4 of the children will have it. If a male has hemophilia, he cannot pass it on. However that…
Bleeding into joints, muscles or soft tissues (sometimes without an obvious injury).
Prolonged bleeding after cuts, bites or minor surgery (e.g. tooth extraction or circumcision).
Bruising on the surface of the skin.
Blood in the urine.
Supplementary tablets that aid in supplementing the missing blood factor (either missing factor VIII or IX)
Medical injections. The intervals of these injections depends on the type of haemophilia the patient has, the severity of the disease…
THE BRAIN &
Presented by: Cassie
Today there is an increase of
children with Manic Depression, also
called Bipolar Disorder, and Autism
Spectrum Disorder. Kids with Bipolar
Disorder can be irritable, angry, and
emotionally very reactive, and their
mood and behavior shifts
unpredictably. Children with Autism
may have some problems including
difficulties with social interaction,
rigid thinking and behavior,
difficulties with language…
Dr.K.Pavithran, MD, DM
Assistant Professor,Dept of Hematology
Medical College Hospital
Is the bleeding significant ?
Local Vs Systemic ?
Platelet Vs Coagulation disorder ?
Inherited Vs Acquired ?
Demonstration of the defect
Identification of the defect(s)
Assessment of severity
Consequential studies eg. carrier detection
Monitoring of treatment