Hereditary Spherocytosis

Diagnosis
For diagnosis of hereditary spherocytosis to take place, the medical history as well as the symptoms of the patients must be known. This may lead to a physical examination to detect disorders that may include antiglobulin, blood tests, coombs tests, liver function tests, osmotic as well as incubated fragility tests and spleen examination. The preciseness of gene combination inherited by the patient may show variation in degrees with which the dominant trait spherocytosis will manifest (Gehrs, Friedberg, 2002).
For a differential diagnosis to take place, the physician must stand the test of distinguishing the symptoms of the disease from those that are similar to it. This is done to ensure that the right diagnosis is conducted to the …show more content…
Nonetheless, in people with this condition, antibodies have been known to bind RBCs and making them potential ‘targets for the immune system’(In Mackay, & In Rose, 2014).This then becomes the ending of the natural lifespan of the RBCs. This often leads to the stepping up of new RBCs production by the body. The challenge is that due to the destruction that takes place, it becomes impossible to maintain the rate with which new RBCs should be produced to outsmart the destructed cells. This, due to this inability, results into a fallen state of RBC in the body leading to anemia (Oksenberg, &Brassat, 2006).
The abnormality that is evident among the red blood cells of hereditary spherocytosis patient results from gene mutations that are related to the protein membranes that provides room for the alteration in shape. This often leads to the cells dysfunctional ability that interferes with the flexibility with which cells are supposed to travel back and forth in the blood. Degradation eventually takes place in the patient’s spleen. This results into hemolytic anemia (Gehrs, Friedberg, …show more content…
Same is the case with AIHA as it has been known that there are several causatives that trigger the condition in a person. Both conditions have been reported to interfere with the normal operations of the red blood cells due to mutations and destructions in hereditary spherocytosis and AIHA respectively (Oksenberg, &Brassat, 2006). The impact realized in both patients have been reported to be in their spleen and this is primarily where treatment takes

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