In the 1960’s a graduate student by the name of Eddie Jessup started performing an experiment in an isolation chamber using himself as the test subject to explore the human consciousness. Eddie has these hallucinations caused by the drugs taken from the Indians. The effects this form of LSD had on him changed not only his genetic and physical appearance but also caused the possibility of memory regression. Psychoactive drugs often have a strong effect on humans, they can bind to certain receptors such a 5-HT and cause neurotransmitters in the brain to enhance feeling, alter reality and cause us to see things that are not there. In the movie Eddie has visions of religious backgrounds although he himself is not religious, which can relate to…show more content… However, anything is possible and in some way maybe this could happen in real life, just not of yet.
LSD interacts with proteins on the surface of brain cells called serotonin receptors. Serotonin is a chemical messenger that helps brain cells communicate. LSD appears to act through a particular receptor called 5-HT2AR. Serotonin receptors activate 2 major signaling pathways within cells: through G-proteins and through β-arrestins. The serotonin receptor closes a lid over the LSD molecule, preventing it from quickly detaching. This likely explains the drug’s long-lasting effects. A mutation increases the mobility of this lid and greatly accelerates LSD’s binding kinetics and selectively dampens LSD-mediated β-arrestin2 recruitment. This reveals an unexpected binding mode of LSD; illuminates key features of its kinetics, stereochemistry, and signaling; and provides a molecular explanation for LSD’s actions at human serotonin receptors (Wang 2017). So theoretically through persistent use of the drug from the Indian tribe and mutations that rapidly accelerate LSD’s
