The first mention of the syndrome of depersonalization-derealization appeared in the late 18th - early 19th century, but the great attention to this pathology also was paid in 1990s, when scientist associated its root causes with a fact of trauma in childhood (Simeon , Guralnik & Schmeidler, 2001). According to the analysis conducted by Medford (2012) almost always depersonalization can be charactarised as a protective mechanism of the brain during severe emotional turmoil, including the debut of severe mental illness. In emergency situations, depersonalization allows to soberly assess the situation, without disturbing the analysis of emotions. In this case, depersonalization is a normal reaction to acute stress. Pathological long-term, ongoing, painful stress consider to be the cause of severe depersonalization.…show more content… Although, some authors linked the deficit of spatial receptor functioning and suppression of emotional responses associated with Brodmann Area 47 (Medford (2012) with the development of depersonalization-derealization syndrome. Further, the current possibilities of computer tomography helped to link chronic dissociative disorders with some neurological etiology such as low activation in the medial prefrontal and the anterior cingulate cortex, inhibitory influence of the prefrontal cortex on the amygdala, high activation in the anterior cingulate cortex and the medial prefrontal cortex and corresponding limbic inhibition. Similar features of brain activity was found by Gentle et al. (2014), who considered them to be the result of severe injuries after car accident, all kinds of various forms of abuse, and
