Course Number: 306
Professor: Barbara Garcia
Student: Sheldon Bennett
Universal vaccination of children against hepatitis A in Chile: a cost-effectiveness study
to the Center of
Disease Control (CDC)
Hepatitis A is caused by infection with the Hepatitis A virus (HAV)
Hepatitis A has an incubation period of approximately 28 days
(range: 15–50 days).
HAV replicates in the liver and is shed in high concentrations in feces from 2 weeks before to 1 week after the onset of clinical illness. HAV infection produces a selflimited disease that does not result in chronic infection or chronic liver disease.
Purpose of Study
Scientist performed the study to evaluate the healthcare and economic impact of routine hepatitis
A vaccination of toddlers in Chile.
Connection Between The Exposure
study showed that the cost of treatment after exposure to
Hepatitis A was far greater than the cost of vaccination per toddler.
Major Techniques Used In The
The scientists used a dynamic model of hepatitis A infection to evaluate the impact of a two dose vaccination program, administered at ages
12 and 18 months.
The Major Results 1
number of hepatitis A infections were reduced from
228,666 to 46,693 and avoiding 107,109 symptomatic cases and 167 deaths, equivalent to annual and average reductions of 76.6% and 59.7%
The Major Results 2
study stated that the sensitivity analyses showed that a coverage rate of 90% would lead to a 72.7% reduction in symptomatic cases and a 52.9% reduction in deaths related to hepatitis
The Major Results Number
study also went on to state that even at a coverage rate of
50%, universal vaccination of toddlers would reduce the numbers of symptomatic cases and deaths by
38.7% and 14.9%, respectively. The Major Results 4
researchers stated that the sensitivity analyses also showed that high levels of herd immunity relative to the base case would reduce symptomatic infection rates and deaths related to hepatitis A by 89.8% and 89.1%, respectively. The Support Of The Hypothesis