Severity and Intensity
Ultraviolet radiation: causes breaks between A-T base pairs and creates T-T dimers
Basal Cell Carcinoma
Squamous Cell Carcinoma
Instead of UV hitting the cell, it hits the melanoma of the cell, which increases its production to protect DNA during process such as tanning i. Chemical carcinogens examples: smoke, red dye #2, asbestos--- There are 49 carcinogens in tobacco smoke including: nitrosamine, formaldehyde, arsenic, nickel, cadmium and benzopyrene j. Viruses---did not transplant cells, just viruses that caused cancer x. Insertion of viral oncogene
Produce viral oncogene protein or produce a protein that can influence adjacent genes.
If the oncogene is viral, it continues to signal cell division, with is carcinogenic virus attached. xi. Inserts near a cellular proto-oncogene
Cellular DNA under the control of the viral promoter 4. Normal Tissue k. Epithelial Sheets: Polarized cells that rest on a basal lamina with an exposed surface 11. Chemically different 12. Organization top and bottom 13. Neighboring cells maintain connections with each other and the basal lamina. l. Connective tissue is extracellular matrix 14. Matrix components are produced inside the cell and secreted 15. Collagen fibers: Protein that provides strength 16. Collagen matrix bound to actin of the cytoskeleton, fibronectin, and integrin. 5. Changes in Cancerous Tissue m. Uncontrolled Cell Division…