Suggest a sample formula of the formulation (and solid dosage form that you like) knowing that the dose is 25 mg per dosage unit and that the drug is sildenafil citrate. How would you go about manufacturing the product?
In order to formulate the sildenafil citrate (25 mg) as a tablet solid dosage form.8 The following components are required, such as a 25 mg sildenafil granules, about 35.08 mg mannitol granules, about 19.54 mg agglomerated granules, about 0.65 mg aspartame, about 0.33 mg lemon flavour and about 0.81 mg magnesium stearate.8 The sildenafil granules can be prepare by adding sildenafil citrate which is our active ingredient with lemon acting as a flavouring agent and aspartame mixed together for some minutes and the addition of citric acid as the buffering agents and stabilizing agent and lactitol as a sweetening agent already dissolve in water and the whole component can be mixed together to give a wet granules.4
The process of wet granulation involves using a liquid binder to lightly agglomerate the powder blend and mixing thoroughly. The amount of liquid added needs to be controlled because over wetting will cause granules to be too hard and under wetting will cause granules to be too soft.4 and this can further be dried.8 The mannitol granules prepared with citric…show more content… In order to formulate the tablet form of all the components, the sildenafil, mannitol and agglomerated granules can be mixed together in a container, then aspartame which is a common sugar free sweetner and lemon flavour can be added and blend together for some minutes, finally magnesium sterate which act as a lubricant to reduce friction between granules and tablet press during compression.4 The reason why magnesium stearate is added last because they are hydrophobic and if care is not taken and too much is used then it can interfere with boding, softening tablets and decreasing hardness.4 and the whole mixture can be blended together.8 Using a rotary press, tablets can then be
