The binding of the acetylcholine to the muscle membrane allows for the initiation of an action potential (which promotes the passing of an electrical current) on the muscle membrane. A special enzyme, acetylcholinesterase, breaks down the released acetylcholine so that it cannot continue to bind to the muscle membrane. In this way, the nerve controls the action of the muscle such that the muscle can only generate a current when the nerve has first generated a current.
The role of acetylcholine in a skeletal contraction is to bind with receptors on the muscle membrane. The binding starts the initiation of the action potential on the muscle membrane. Acetylcholinesterase, the enzyme, breaks down the acetylcholine that was released so it doesn't bind to the muscle membrane anymore.
ACH is released at the end-plate potential. ACH diffuses into the sarcolemma, attaches to the receptors in the motor end plate and causes a change in the ions permeability that creates graded depolarization of the end-plate potential. Basically, it attaches to the receptors in the motor-end plate and creates the beginning process of triggering muscle contractions.
During the process of excitation-contraction coupling in skeletal muscle, calcium is released from the sarcoplasmic reticulum by which of the following?
Depolarization of the T…