Traumatic Brain Injury: Advanced Tract-Based Analysis

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In the study titled “White matter disruption in moderate/severe pediatric traumatic brain injury: Advanced tract-based analyses”, the authors sought to investigate a possible correlation between Traumatic Brain Injury (TBI) during development, and the magnitude and area of white matter (WM) disruptions, primarily occurring in the corpus callous. These alterations of WM can subsequently affect cognitive functions that are supported by the WM tracts that were disrupted due to injury. Intact white matter is essential for efficient, healthy, brain function. Additionally, increasing myelination of WM tracts occurs well into the third decade of life. Implying that an injury that disrupts WM tracts during development, may affect the continual myelination of these tracts, and the ability of these tracts to support higher cognitive processes. The goal of the study was to attempt to answer questions about how a TBI during development impacts WM integrity, and the extent to which the disruptions are linked with particular cognitive impairs post TBI. TBI participants of the study were recruited from four Pediatric Intensive Care units. Parents of the patients were to give permission for the investigators to contact them upon discharge. In order, to obtain results for post-TBI, 28 children with …show more content…
This decreased in the CC can be linked to more difficulty with bimanual tasks. The researchers assessed participants’ cognitive function with six different measures; finding multiple associations between the patients scores on the cognitive tests and WM tract integrity. They found that better processing speed was associated with a higher FA and lower MD/RD in the CC. The methods used in this study enabled the WM integrity of patients to be assessed more robustly and
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