A major negative consequence that resulted from the Columbian Exchange. The foods might have diseases like smallpox, chicken pow, yellow fever. these diseases can lead to death. That is why they dident trust the foods and dident eat them often.
In the exchange, there were many items taken from the Americas (New World) to Europe (Old World). These things were like wild carts and land animals. They will give these items to help the others not to affect the