DEFINITION According to CDC, Ebola also called Ebola virus disease is defined as one the rare and deadly killing virus on earth. Virus itself is a microscopic pathogens which causes a disease, affect humans, animals or plants. This virus spread from person to person or animal to person. A virus can be classified as being composed of RNA or DNA molecule. In this particular case, Ebola is classified as RNA virus.
Our work consist of breaking down the Origin (outbreak), pathology, transmission, signs and symptoms, treatment and how the disease outbreak are controlled The first case of Ebola virus appeared in 1976 with two simultaneous outbreak in Soudan and Zaire actual Republic Democratic of Congo. Because the latter outbreak occurred in a village near the Ebola River from which is how the disease was named. These two countries are located central Africa near tropical rainforest. In 1976 to 1995 four cases were documented. In 1976 the outbreak caused 340 deaths out 568 cases. Three years later, in Soudan, the small outbreak caused 22 fatalities out 32 cases. Finally in 1995, it reoccurred in Zaire” Kikwit”, according to the World Health Organization (WHO), a total of total of 315 cases were reported leading to 244 deaths, all of these previous occurrences were classified as epidemic ,since only some specific regions were affected by the disease. Very unknown worldwide, The October of 2014 Ebola outbreak became the largest in the history, affecting many countries in West Africa” (Liberia, Sierra Leone, Guinea and Nigeria). The virus was transmitted to United State of America and Europe from healthcare workers who were affected. A total of 13241 cases were recorded and 4949 death occurred in Africa and one death in Texas’s”. Scientifically what is Ebola virus? When the first case of Ebola happened, local heath institutions handled is as malaria disease that is transmitted by mosquito’s bites. Because of the severity of this virus, WHO and CDC experts worked together to find out that the Ebola virus show the same side effects as malaria. But more virulent There four different strains of the Ebola virus Zaire (EBOZ), Sudan (EBOS), Tai (EBOT) and Reston (EBOR). These strains are very similar except for small serological differences and sequence differences. The Reston Strains is the only one which does not affect humans.
Thus Ebola virus is a negative stranded RNA viruses known as filo viruses. Microscopically, Ebola virus looks like long filaments and are threadlike shape with U form. The average length and diameter of Ebola virus is respectively 920 nm and 80 nm. On the virus surface, there are many spikes or binding sites. The Ebola virons are variable in length and virus consists of helical nucleocapsid. It’s the protein coat and the nucleic acid it encloses. The virus is composed of 7 polypeptides, nucleoprotein, a polymerase and 4 undesignated proteins, synthetized by mRNA and transcribed by the RNA of the virus.in the order of 3’ untranslated region, nucleoprotein, viral structured protein, VP35, VP40, glycoprotein, VP30, VP24, polymerase(L), and 5’ untranslated region.
Once the virus enters the body, it travels through the blood stream and it replicated in many organs. The mechanism used to penetrate the membranes of cells and enter the cell is unclear, but once inside the host cells, The RNA is transcribed and replicated, producing mRNA which are used to produce the virus proteins. The RNA is replicated inside the cytoplasm and is mediated by the synthesis of an antisense RNA strand which serves as a temple for producing additional Ebola genomes. As the infections progresses, the cytoplasm develops prominent inclusion bodies, It then assembles and buds off from the host cell while obtaining its lipoprotein coat from the outer membrane, leading to the immediate destruction of the host while produce producing large numbers of viruses budding from it. Technically we can resume by